Drug NameTriamterene (Triamterene/ Hydrochlorothiazide) Drug UsesTriamterene pill combines Triamterene and Hydrochlorothiazide. Triamterene ia potassium-conserving (antikaliuretic) diuretic with relatively weak natriuretic properties. Hydrochlorothiazide is a diuretic and antihypertensive agent. It blocks the renal tubular absorption of sodium and chloride ions. How to useUse Triamterene as directed by your doctor.
- Take Triamterene by mouth with food.
- If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water.
Ask your health care provider any questions you may have about how to use Triamterene. Drug Class and MechanismTriamterene is a potassium-conserving (antikaliuretic) diuretic with relatively weak natriuretic properties. It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen. With this action, triamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazide. Triamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison's disease, i.e., without aldosterone. Triamterene's onset and duration of activity is similar to hydrochlorothiazide.
Hydrochlorothiazide is a diuretic and antihypertensive agent. It blocks the renal tubular absorption of sodium and chloride ions. This natriuresis and diuresis is accompanied by a secondary loss of potassium and bicarbonate. Onset of hydrochlorothiazide's diuretic effect occurs within two hours and the peak action takes place in four hours. Diuretic activity persists for approximately six to twelve hours. Missed DoseIf you miss a dose of Triamterene and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Storage Store Triamterene at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Triamterene out of the reach of children and away from pets. Possible Side EffectsCheck with your doctor if any of these most common side effects persist or become bothersome:
- diarrhea; headache; loss of appetite; nausea; weakness.
Seek medical attention right away if any of these severe side effects occur:
- severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dry mouth; excessive thirst; slow or irregular heart rate; unusual muscle weakness; unusual tiredness; vomiting; yellowing of the skin or eyes.
More InformationTriamterene is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor. Warnings/PrecautionsDo not use Triamterene if:
- you are allergic to any ingredient in Triamterene;
- you are taking potassium supplements, another potassium-sparing diuretic (e.g., amiloride), or an aldosterone blocker (e.g., eplerenone);
- you are unable to urinate or have high blood potassium levels or severely decreased liver or kidney function.
Contact your doctor or health care provider right away if any of these apply to you.
Important:
- Triamterene may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Triamterene with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Check with your doctor before you use a salt substitute or a product that has potassium in it.
- Tell your doctor or dentist that you take Triamterene before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including blood electrolytes, blood cell counts, kidney and liver function tests, blood uric acid levels, and blood pressure, may be performed while you use Triamterene. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Triamterene with caution in the elderly; they may be more sensitive to its effects.
- Triamterene should not be used in children; safety and effectiveness in children have not been confirmed.
- Pregnancy and breast-feeding: It is not known if Triamterene can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Triamterene while you are pregnant. It is not known if Triamterene is found in breast milk. Do not breast-feed while taking this medicine.
What is triamterene?
Triamterene is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.
Triamterene is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney condition called nephrotic syndrome.
Triamterene is also used to treat edema caused by having too much aldosterone in your body. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in your body.
Triamterene may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about triamterene?
Do not use this medication if you have kidney disease, urination problems, severe liver disease, or high levels of potassium in your blood. Do not use potassium supplements or other diuretics while you are taking triamterene.
Before using this medication, tell your doctor if you have heart or liver disease, diabetes, gout, or a history of kidney stones. Tell your doctor if you are using another diuretic.
Avoid drinking alcohol, which can increase some of the side effects of triamterene.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking triamterene.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
What should I discuss with my doctor before taking triamterene?
Do not use this medication if you have:
- kidney disease or are unable to urinate;
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severe liver disease;
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high potassium levels (hyperkalemia); or
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if you are taking potassium supplements, or another potassium-sparing diuretic such as Dyazide, Maxzide, amiloride (Midamor, Moduretic), or spironolactone (Aldactone, Aldactazide).
Before using triamterene, tell your doctor if you have:
If you have any of these conditions, you may not be able to use triamterene, or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Triamterene may pass into breast milk and could cause harm to a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take triamterene?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.
Take each dose with a full glass of water. Take this medication after eating a meal.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.
Triamterene can interfere with the results of certain medical tests. Tell any doctor who treats you that you are using triamterene.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking triamterene. You may need to stop using the medicine for a short time.
Store this medication at room temperature away from heat, light, and moisture.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a triamterene overdose may include increased urination, nausea, vomiting, weakness, fever, warmth or flushing in your face, or muscle spasms.
What should I avoid while taking triamterene?
Avoid drinking alcohol, which can increase some of the side effects of triamterene.
Avoid using other medicines that make you light-headed (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to the side effects of triamterene.
Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking triamterene.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Triamterene side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
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numbness or tingly feeling;
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muscle pain or weakness;
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slow, fast, or uneven heartbeat;
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feeling drowsy, restless, or light-headed;
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urinating less than usual or not at all;
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shallow breathing;
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tremors, confusion; or
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nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Continue using triamterene and talk with your doctor if you have any of these less serious side effects:
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Triamterene Dosing Information
Usual Adult Dose for Ascites: Initial dose: 100 mg orally twice a day. Usual Adult Dose for Edema: Initial dose: 100 mg orally twice a day. Usual Pediatric Dose for not applicable: > 1 year: Initial dose: 4 mg/kg/ day in 1 to 2 divided doses.
May increase to 6 mg/kg/day in 1 to 2 divided doses.
What other drugs will affect triamterene?
Before taking this medication, tell your doctor if you are using any of the following drugs:
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lithium;
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insulin or diabetes medicine taken by mouth;
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an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
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indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.
If you are using any of these drugs, you may not be able to use triamterene, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect triamterene. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
- Your pharmacist has additional information about triamterene written for health professionals that you may read.
What does my medication look like?
Triamterene is available with a prescription under the brand name Dyrenium. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
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