Drug NameTrandate (Labetalol) Drug UsesThis medication is used to treat severe high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems. How to useFollow the directions for using this medicine provided by your doctor. Take this medicine with food or milk. Drug Class and MechanismTrandate is a drug that is used for treating high blood pressure. It is related to carvedilol (Coreg). Nerves that are part of the adrenergic nervous system travel to most arteries where they release an adrenergic chemical norepinephrine. The norepinephrine attaches to receptors on the muscles of the arteries and causes the muscles to contract, narrowing the arteries, and increasing the blood pressure. Trandate blocks receptors of the adrenergic nervous system. When trandate attaches to and blocks the receptors, the arterial muscles relax, and the arteries expand, resulting in a fall in blood pressure. The FDA first approved Trandate in 1997. Missed DoseIf the dose is interrupted, contact the doctor immediately to re-establish dosing. Storage Store the vials at room temperature between 36 and 86 degrees F (2 to 30 degrees C) and away from light. Do not freeze. After dilution in the correct IV fluids, this product is stable for 24 hours refrigerated or at room temperature. Discard any unused liquid. Possible Side EffectsFatigue, nausea, or tingling of the scalp/skin may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if this potentially serious side effect occurs: dizziness. Tell your doctor immediately if these unlikely but serious side effects occur: fainting, leg pain, increased sweating, increased urination, unusual thirst. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: unusually slow or irregular heartbeat, persistent loss of appetite, stomach pain, persistent sore throat or fever, easy bleeding or bruising, vision changes, difficulty urinating, mental/mood changes. Rare, but possibly fatal, liver problems have occurred during labetalol use. Seek immediate medical attention if you develop: dark urine, yellowing eyes or skin. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, call your doctor or pharmacist. More InformationLaboratory and/or medical tests (e.g., liver function) may be performed to monitor your progress. Warnings/PrecautionsTell your doctor your medical history, especially of: liver problems, heart problems (e.g., mild/moderate congestive heart failure), pheochromocytoma, diabetes, any allergies. This medication is not recommended for use if you have the following medical conditions: lung disease (asthma, COPD), certain heart problems (e.g. advanced heart block, severe bradycardia, severe heart failure, post-CABG surgery). This drug may make you dizzy for up to 3 hours after it is given. You should remain lying down during this time period in order to prevent falls. You should get up slowly when rising from a seated or lying position; another person should assist you. Use caution when performing activities that require alertness such as driving or using machinery. Limit alcoholic beverages. If you have a history of severe allergic reactions, consult your doctor or pharmacist. Normal doses of epinephrine may not be as effective while you are using this medication. If you are diabetic, this drug may block certain symptoms of low blood sugar. Increased sweating is a symptom that is not affected. Consult your doctor or pharmacist for more details. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. Trandate should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breast-feeding.
What is Trandate (labetalol)?
Labetalol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
Labetalol is used to treat hypertension (high blood pressure).
Labetalol may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Trandate (labetalol)?
Do not stop taking labetalol without first talking to your doctor. Stopping suddenly may make your condition worse.
If you need to have any type of surgery, you may need to temporarily stop using labetalol. Be sure the surgeon knows ahead of time that you are using labetalol.
Labetalol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking labetalol.
Labetalol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.
Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.
What should I discuss with my healthcare provider before taking Trandate (labetalol)?
Before taking labetalol, tell your doctor if you have:
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asthma, bronchitis, emphysema;
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diabetes;
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low blood pressure;
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a heart problem such as heart block, sick sinus syndrome, slow heart rate, or congestive heart failure;
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depression;
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liver or kidney disease;
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a thyroid disorder;
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myasthenia gravis;
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pheochromocytoma; or
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problems with circulation (such as Raynaud's syndrome).
If you have any of these conditions, you may not be able to use labetalol, or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Labetalol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using labetalol.
How should I take Trandate (labetalol)?
Take labetalol exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor.
Take this medication with a full glass of water.
Take labetalol at the same time every day.
Do not skip doses or stop taking labetalol without first talking to your doctor. Stopping suddenly may make your condition worse.
To be sure this medication is helping your condition, your blood pressure will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.
If you need to have any type of surgery, tell the surgeon that you are using labetalol. You may need to briefly stop using labetalol before having surgery.
Labetalol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.
Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.
Store labetalol at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If your next dose is less than 8 hours away, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Symptoms of a labetalol overdose may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions).
What should I avoid while taking Trandate (labetalol)?
Labetalol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking labetalol.
Trandate (labetalol) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
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slow or uneven heartbeats;
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feeling light-headed, fainting;
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feeling short of breath, even with mild exertion;
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swelling of your ankles or feet;
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nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
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depression; or
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cold feeling in your hands and feet.
Other less serious side effects are more likely to occur, such as:
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decreased sex drive, impotence, or difficulty having an orgasm;
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sleep problems (insomnia);
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tired feeling; or
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anxiety, nervousness.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect Trandate (labetalol)?
Before taking labetalol, tell your doctor if you are using:
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allergy treatments (or if you are undergoing allergy skin-testing);
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clonidine (Catapres);
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guanabenz (Wytensin);
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an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam);
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a diabetes medication such as insulin, glyburide (Diabeta, Micronase, Glynase), glipizide (Glucotrol), chlorpropamide (Diabinese), or metformin (Glucophage);
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a heart medication such as nifedipine (Procardia, Adalat), reserpine (Serpasil), verapamil (Calan, Verelan, Isoptin), diltiazem (Cartia, Cardizem);
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medicine for asthma or other breathing disorders, such as albuterol (Ventolin, Proventil), bitolterol (Tornalate), metaproterenol (Alupent), pirbuterol (Maxair), terbutaline (Brethaire, Brethine, Bricanyl), and theophylline (Theo-Dur, Theolair); or
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cold medicines, stimulant medicines, or diet pills.
If you are using any of these drugs, you may not be able to take labetalol, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect labetalol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
- Your pharmacist has additional information about labetalol written for health professionals that you may read.
What does my medication look like?
Labetalol is available with a prescription under the brand names Normodyne and Trandate. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
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Normodyne 100 mg--round, light-brown, scored, film-coated tablets
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Normodyne 200 mg--round, white, scored film-coated tablets
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Normodyne 300 mg--round, blue, film-coated tablets
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Trandate 100 mg--round, light-orange, scored, film-coated tablets
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Trandate 200 mg--round, white, scored, film-coated tablets.
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Trandate 300 mg--round, peach, scored, film-coated tablets
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