Drug NameHyzaar (Losartan/Hydrochlorothiazide) Drug UsesHyzaar is used for treating high blood pressure and decreases the risk of stroke. How to useUse Hyzaar as directed by your doctor.
- Take Hyzaar by mouth with or without food.
- Drinking extra fluids while you are taking Hyzaar is recommended. Check with your doctor for instructions.
- Hyzaar may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
- If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Hyzaar.
- Continue to use Hyzaar even if you feel well. Do not miss any doses.
Ask your health care provider any questions you may have about how to use Hyzaar. Drug Class and MechanismHyzaar is a combination angiotensin II receptor blocker and diuretic. The angiotensin II receptor blocker works by relaxing the blood vessels. Exactly how the diuretic works to decrease blood pressure is unknown, but it helps the kidneys to eliminate fluid and sodium from the body. Missed DoseIf you miss a dose of Hyzaar, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Storage Store Hyzaar at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hyzaar out of the reach of children and away from pets. Possible Side EffectsCheck with your doctor if any of these most common side effects persist or become bothersome:
- back pain; diarrhea; dizziness; lightheadedness, especially when sitting up or standing; nausea; numbness or tingling of the skin; tiredness.
Seek medical attention right away if any of these severe side effects occur:
- severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decrease in sexual ability; decreased urination; depression; drowsiness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; hoarseness; muscle pain, tenderness, or cramps; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent dry mouth; shortness of breath; swelling of the arms or legs; unusual bruising or bleeding; unusual thirst; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.
More InformationHyzaar is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor. Warnings/PrecautionsDo not use Hyzaar if:
- you are allergic to any ingredient in Hyzaar or to any other sulfonamide medicine (eg, sulfamethoxazole) ;
- you are pregnant;
- you have severe liver or kidney problems or are unable to urinate;
- you are taking dofetilide or ketanserin.
Contact your doctor or health care provider right away if any of these apply to you.
Important :
- Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Report any lightheadedness or fainting to your doctor immediately. Your risk of lightheadedness or fainting may be increased if you experience diarrhea, vomiting, excessive sweating, if you do not drink enough fluids, or if you are on a low-salt diet.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal. Tell your doctor if you develop any new symptoms.
- Hyzaar may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hyzaar. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Tell your doctor or dentist that you take Hyzaar before you receive any medical or dental care, emergency care, or surgery.
- If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
- Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
- Diabetes patients - Hyzaar may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Hyzaar may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Hyzaar has not been shown to reduce the risk of stroke or certain heart problems in black patients who have high blood pressure.
- Hyzaar may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Hyzaar.
- Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Hyzaar. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Hyzaar should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
- Pregnancy and breast-feeding: Hyzaar may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Hyzaar is found in breast milk. Do not breast-feed while taking Hyzaar.
What is hydrochlorothiazide and losartan?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Losartan is in a group of drugs called angiotensin II receptor antagonists. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
The combination of hydrochlorothiazide and losartan is used to treat high blood pressure (hypertension) and to reduce the risk of stroke in people with hypertension.
Hydrochlorothiazide and losartan may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about hydrochlorothiazide and losartan?
Do not use this medication if you are allergic to hydrochlorothiazide or losartan, or if you are unable to urinate. Do not use this medication without telling your doctor if you are pregnant. Losartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.
Before using hydrochlorothiazide and losartan, tell your doctor if you have congestive heart failure, kidney or liver disease, asthma, low or high blood levels of potassium, gout, lupus, diabetes, or an allergy to sulfa drugs.
Hydrochlorothiazide and losartan can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and losartan.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and losartan, unless your doctor has told you to. In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.
What should I discuss with my healthcare provider before taking hydrochlorothiazide and losartan?
Do not use this medication if you are allergic to hydrochlorothiazide or losartan, or if you are unable to urinate.
Before using hydrochlorothiazide and losartan, tell your doctor if you have:
- kidney disease;
- liver disease;
-
congestive heart failure;
-
asthma or allergies;
-
low or high levels of potassium in your blood;
-
gout;
-
lupus;
-
diabetes; or
-
an allergy to sulfa drugs.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take hydrochlorothiazide and losartan.
FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use this medication without telling your doctor if you are pregnant. Losartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. It is not known whether hydrochlorothiazide and losartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
How should I take hydrochlorothiazide and losartan?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take this medication with a full glass (8 ounces) of water.
To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Your kidney function may also need to be tested. Do not miss any scheduled appointments.
Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.
If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.
Store hydrochlorothiazide and losartan at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.
What should I avoid while taking hydrochlorothiazide and losartan?
Hydrochlorothiazide and losartan can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and losartan.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and losartan, unless your doctor has told you to.
Hydrochlorothiazide and losartan side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine. Stop using this medication and call your doctor at once if you have a serious side effect such as:
-
feeling light-headed, fainting;
-
swelling, rapid weight gain;
-
fast or pounding heartbeats;
-
urinating more or less than usual, or not at all;
-
jaundice (yellowing of the skin or eyes); or
-
dry mouth, increased thirst, drowsiness, restless feeling, confusion, increased urination, fast heart rate, fainting, or seizure (convulsions).
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
What other drugs will affect hydrochlorothiazide and losartan?
Before taking hydrochlorothiazide and losartan, tell your doctor if you are using any of the following drugs:
-
any other blood pressure medications;
-
steroids (prednisone and others);
-
lithium (Eskalith, Lithobid);
-
celecoxib (Celebrex) or valdecoxib (Bextra);
-
cholestyramine (Prevalite, Questran) or colestipol (Colestid);
-
rifampin (Rifadin, Rimactane, Rifater);
-
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
-
any other diuretics, such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others;
-
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;
-
a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex);
-
a narcotic medication such as hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin), oxymorphone (Numorphan), or propoxyphene (Darvon, Darvocet).
This list is not complete and there may be other drugs that can interact with hydrochlorothiazide and losartan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
- Your pharmacist can provide more information about hydrochlorothiazide and losartan.
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