Drug NameDipyridamole Drug UsesDipyridamole keeps the platelets in your blood from coagulating (clotting) and is used to prevent blood clots from forming on or around an artificial heart valve. How to useUse Dipyridamole as directed by your doctor.
- Take Dipyridamole by mouth with or without food.
Ask your health care provider any questions you may have about how to use Dipyridamole. Drug Class and MechanismDipyridamole is a coronary vasodilator. It works by increasing blood flow to the heart, which mimics an exercise test. It is followed by the thallium test. Missed DoseIf you miss a dose of Dipyridamole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Storage Store Dipyridamole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Dipyridamole out of the reach of children and away from pets. Possible Side EffectsCheck with your doctor if any of these most common side effects persist or become bothersome:
- dizziness; fatigue; flushing; headache; nausea.
Seek medical attention right away if any of these severe side effects occur:
- severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fast, irregular, or slow heartbeat; one-sided weakness; seizures; slurred speech.
More InformationDipyridamole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor. Warnings/PrecautionsDo not use Dipyridamole if:
- you are allergic to any ingredient in Dipyridamole.
Contact your doctor or health care provider right away if any of these apply to you. Important :
- Dipyridamole may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Dipyridamole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Avoid food or drink that has caffeine (e.g., coffee, tea, cocoa, cola, chocolate) before you use Dipyridamole.
- Dipyridamole should not be used in children; safety and effectiveness in children have not been confirmed.
- Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dipyridamole while you are pregnant. Dipyridamole is found in breast milk. Do not breast-feed while taking Dipyridamole.
What is dipyridamole?
Dipyridamole keeps the platelets in your blood from coagulating (clotting) to prevent blood clots from forming on or around an artificial heart valve.
Dipyridamole is used to prevent blood clots after heart valve replacement surgery.
Dipyridamole may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about dipyridamole?
Before taking dipyridamole, tell your doctor if you have liver disease, low blood pressure, coronary artery disease, angina (chest pain), or if you have recently had a heart attack.
Dipyridamole is often taken together with other medications to prevent blood clots. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.
To be sure this medication is not causing harmful effects, your doctor may need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.
While you are taking dipyridamole, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.
There may be other drugs that can affect dipyridamole. During your treatment with dipyridamole, you may also be taking another blood thinner such as warfarin (Coumadin). There are many drugs that can interact with blood thinners.
Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
What should I discuss with my healthcare provider before taking dipyridamole?
Do not use this medication if you are allergic to dipyridamole.
Before taking dipyridamole, tell your doctor if you are allergic to any drugs, or if you have:
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liver disease;
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low blood pressure;
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severe coronary artery disease (also called atherosclerosis);
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uncontrolled chest pain (angina); or
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if you have recently had a heart attack.
If you have any of these conditions, you may not be able to use dipyridamole, or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Dipyridamole can pass into breast milk and may harm a nursing infant. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 12 years old without the advice of a doctor.
How should I take dipyridamole?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Take dipyridamole with a full glass (8 ounces) of water.
Dipyridamole is often taken together with other medications to prevent blood clots. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.
To be sure this medication is not causing harmful effects, your doctor may need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.
Store dipyridamole at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include sweating, warmth or tingly feeling under your skin, dizziness, weakness, restlessness, fast heart rate, feeling light-headed, or fainting.
What should I avoid while taking dipyridamole?
While you are taking dipyridamole, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.
Dipyridamole side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
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nosebleed or other bleeding that will not stop;
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black, bloody, or tarry stools; or
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coughing up blood or vomit that looks like coffee grounds.
Less serious side effects may include:
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dizziness;
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upset stomach, diarrhea, vomiting;
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warmth, redness, or tingly feeling under your skin;
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muscle or joint pain;
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headache; or
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mild skin rash or itching.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Dipyridamole Dosing Information
Usual Adult Dose for Prosthetic Heart Valves: Thromboembolic prophylaxis: 75 to 100 mg orally 3 to 4 times a day. Given as an adjunct to warfarin. Aspirin 80 to 100 mg may be given instead of dipyridamole. Usual Adult Dose for Radionuclide Myocardial Perfusion Study: 0.57 mg/kg (up to 60 mg) IV over 4 minutes. Usual Pediatric Dose for not applicable: 3 to 6 mg/kg/day orally in 3 divided doses. Doses of 4 to 10 mg/kg/day have been used to treat proteinuria in pediatric renal disease.
What other drugs will affect dipyridamole?
There may be other drugs that can affect dipyridamole. During your treatment with dipyridamole, you may also be taking another blood thinner such as warfarin (Coumadin). There are many drugs that can interact with blood thinners.
Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
- Your pharmacist has information about dipyridamole written for health professionals that you may read.
What does my medication look like?
Dipyridamole is available with a prescription under the brand name Persantine. Other brand or generic forms may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
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Persantine 25 mg--round, orange, sugar-coated tablets
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Persantine 50 mg--round, orange, sugar-coated tablets
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Persantine 75 mg--round, orange, sugar-coated tablets
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