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Blood Pressure/Cholesterol

Clonidine
Clonidine
Clonidine is an alpha agonist that is used for treating high blood pressure.

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Drug Name

Clonidine

Drug Uses

Clonidine is used for treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

How to use

Use Clonidine as directed by your doctor.

Take Clonidine by mouth with or without food.
Take Clonidine on a regular schedule to get the most benefit from it.
Continue to take Clonidine even if you feel well. Do not miss any doses.

Ask your health care provider any questions you may have about how to use Clonidine.

Drug Class and Mechanism

Clonidine is an alpha agonist. It works by relaxing blood vessels and decreasing heart rate, which lowers blood pressure.

Missed Dose

If you miss a dose of Clonidine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Clonidine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Clonidine out of the reach of children and away from pets.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

constipation; dizziness; drowsiness; dry mouth; nausea; tiredness; vomiting.

Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat; hallucinations; mental or mood changes; severe or persistent headache or dizziness; swelling of the hands, ankles, or feet.

More Information

Clonidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

Warnings/Precautions

Do not use Clonidine if:

you are allergic to any ingredient in Clonidine.

Contact your doctor or health care provider right away if any of these apply to you.

Important :

Clonidine may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Clonidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Clonidine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
Talk to your doctor before using alcohol or medicines that may cause drowsiness (e.g., sleep aids, muscle relaxers) while you are using Clonidine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
Tell your doctor or dentist that you take Clonidine before you receive any medical or dental care, emergency care, or surgery.
Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal. Tell your doctor if you develop any new symptoms.
If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
If you experience dry mouth, use sugarless candy or gum, or melt bits of ice in your mouth to help keep your mouth moist.
Do not suddenly stop taking Clonidine without talking to your doctor. Nervousness, agitation, confusion, tremor, and headache may occur. These may be followed by a rapid, severe rise in blood pressure. You may be at greater risk if you use high doses or if you also take a beta-blocker (e.g., propranolol). If you need to stop taking Clonidine, follow your doctor's instructions for slowly decreasing your dose.
Lab tests, including blood pressure, may be performed while you take Clonidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Clonidine with caution in the elderly; they may be more sensitive to its effects, especially dizziness.
Clonidine should be used with extreme caution in children younger than 12 years old; safety and effectiveness in these children have not been confirmed.
Use Clonidine with extreme caution in children unable to take oral medicines due to vomiting; they may have a higher risk of developing withdrawal symptoms, including severe high blood pressure.
Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clonidine while you are pregnant. Clonidine is found in breast milk. If you are or will be breast-feeding while you use Clonidine, check with your doctor. Discuss any possible risks to your baby.

What is clonidine?

Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.

Clonidine is used to treat hypertension (high blood pressure). It is sometimes used together with other blood pressure medications.

Clonidine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about clonidine?

Before you take clonidine, tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS).

Do not stop taking this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, agitation, headache, tremors, severe high blood pressure, or life-threatening symptoms. Talk with your doctor about how to avoid withdrawal symptoms when you stop taking clonidine. Avoid drinking alcohol. It can increase some of the side effects of clonidine.

Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Clonidine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

What should I discuss with my healthcare provider before taking clonidine?

You should not take this medication if you are allergic to clonidine.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take clonidine, tell your doctor if you have:

heart disease or severe coronary artery disease;
a heart rhythm disorder;
a history of heart attack or stroke;
kidney disease; or
if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS).

FDA pregnancy category C. It is not known if clonidine is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Clonidine can pass into breast milk and may harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 12 years old.

How should I take clonidine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Clonidine is usually taken in the morning and at bedtime. Follow your doctor's instructions.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking clonidine. You may need to stop using the medicine for a short time. Do not stop taking this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, agitation, headache, tremors, severe high blood pressure, or life-threatening symptoms. Talk with your doctor about how to avoid withdrawal symptoms when you stop taking clonidine.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store this medication at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath) followed by low blood pressure (feeling light-headed, fainting), drowsiness, cold feeling, slow heart rate, shallow breathing, weakness, fainting, or pinpoint pupils.

What should I avoid while taking clonidine?

Avoid drinking alcohol. It can increase some of the side effects of clonidine. Clonidine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Clonidine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

fast or pounding heartbeats;
a very slow heart rate (fewer than 60 beats per minute);
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
confusion, hallucinations;
fever, pale skin;
urinating less than usual or not at all; or
feeling like you might pass out.

Less serious side effects may include:

feeling dizzy, drowsy, tired, or nervous;
dry mouth;
dry or burning eyes, blurred vision;
headache, muscle or joint pain;
nausea, vomiting, constipation, loss of appetite;
sleep problems (insomnia);
urinating more at night;
mild skin rash or itching; or
decreased sex drive, impotence.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Clonidine Dosing Information

Usual Adult Dose for Hypertension:

Initial dose (PO): 0.1 mg orally twice a day (morning and bedtime).
Maintenance dose: 0.2 to 0.6 mg/day given in divided doses.

Initial dose (patches):Clonidine TTS-1 (0.1 mg/24 hr) applied once a week.
Maintenance dose: If after 1 to 2 weeks the desired reduction in blood pressure is not achieved, increase the dosage by adding another TTS-1 film or changing to a larger system.
An increase in dosage above 2 clonidine TTS-3 films is usually not associated with additional efficacy.

Usual Adult Dose for Pain:

Continuous Epidural Infusion:
Initial dose: 30 mcg/hr.
May be titrated up or down depending on pain relief and occurrence of adverse events.
Maximum dose 40 mcg/hr.

Usual Adult Dose for Pheochromocytoma Diagnosis:

0.3 mg orally once. Clonidine is only recommended after baseline determination of plasma catecholamines. Two baseline samples can be obtained five minutes apart from an existing IV line after the patient has remained supine for 90 minutes (a new needle stick could increase catecholamine concentrations and foul the test).
After the initial dose of clonidine, three additional hourly blood samples may be obtained for plasma catecholamine concentration measurements.
Generally, patients with hypertension and pheochromocytoma do NOT show a decrease in plasma catecholamine levels after this "suppression test", whereas hypertensive patients without pheochromocytoma do. False negative tests have been reported.

Usual Adult Dose for Hypertensive Emergency:

0.2 mg orally once. Additional doses of 0.1 mg may be given as needed and tolerated every hour to control this patient's blood pressure. Be cognizant of the risk of stroke or heart attack or other problem associated with aggressive blood pressure reduction, especially in older persons. The maximum recommended total daily dose in any case of emergent hypertension is 0.8 mg.

Some clinicians report a poor antihypertensive effect of clonidine in patients with spinal injuries since this drug acts on the central nervous system to inhibit peripheral sympathetic tone, and the central and peripheral nervous systems are disrupted in these patients.

Usual Adult Dose for Alcohol Withdrawal: